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22 Gen Unconventional NMDA Receptor Signaling

Posted at 20:43h in Publications by Peptitech Team 0 Comments

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In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic membrane, where they act via Ca 2 to signal coincidence detection in Hebbian plasticity. More recently, it has been established that NMDAR-mediated transmission can be dynam- ically regulated by neural activity. In...

22 Gen Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release

Posted at 20:30h in Publications by Peptitech Team 0 Comments

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Activation of c-Jun N-terminal kinase (JNK) signaling pathway is a critical step for neuronal death occurring in several neurological conditions. JNKs can be activated via receptor tyrosine kinases, cytokine receptors, G-protein coupled receptors and ligand-gated ion channels, including the NMDA glutamate receptors. While JNK has...